Does SINE evolution preclude Alu function?

SURVEY AND SUMMARY Does SINE evolution preclude Alu function?

The evolution, mobility and deleterious genetic effects of human Alus are fairly well understood. The complexity of regulated transcriptional expression of Alus is becoming apparent and insight into the mechanism of retrotransposition is emerging. Unresolved questions concern why mobile, highly repetitive short interspersed elements (SINEs) have been tolerated throughout evolution and why and h...

Alu-SINE exonization: en route to protein-coding function.

The majority of more than one million primate-specific Alu elements map to nonfunctional parts of introns or intergenic sequences. Once integrated, they have the potential to become exapted as functional modules, e.g., as protein-coding domains via alternative splicing. This particular process is also termed exonization and increases protein versatility. Here we investigate 153 human chromosoma...

Alu in Lynch syndrome: a danger SINE?

Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline loss of a DNA mismatch repair gene. In a significant proportion of cases, loss of function of the MSH2 mismatch repair gene is caused by large heterogeneous deletions involving MSH2 and/or the adjacent EPCAM gene. These deletions usually result from homologous malrecombination events between Alu elements, a family ...

Does omentoplasty preclude cardiac retransplantation?

Preclude Recoverable Function Failure to Visualize Acutely Injured Kidneys with Technetium-99m DMSA Does Not

J Nucl Med. Andrew Taylor, Jr., Frederick Akiya and Martin C. Gregory Preclude Recoverable Function Failure to Visualize Acutely Injured Kidneys with Technetium-99m DMSA Does Not http://jnm.snmjournals.org/content/27/3/377 This article and updated information are available at: http://jnm.snmjournals.org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http...